［Objective］The Zedang wide valley basin of the Yarlung Zangbo River is one of the regions where desertified land is difficult to manage. The key to address this issue is to establish a scientific model of desertification prevention and control.［Methods］ Remote sensing images were used to identify the spatial distribution and temporal evolution characteristics of desertified land. The geographical detector was employed to assess the factors influencing desertification，propose management zoning and modes，and establish priorities for future management areas.［Results］1）Desertified land was mainly distributed along both banks of the Yarlung Zangbo River，with desertification on the north bank being significantly more severe than that on the south bank. In 2020， the desertified area was 407.20 km²， a decrease of 47.13 km² compared to 2000， indicating that desertification prevention and control had achieved certain effectiveness. 2）The main factors influencing land desertification were annual average wind speed，annual average temperature，annual evaporation，and altitude， and socio-economic factors had a relatively great impact on local desertification. 3）Based on factors such as altitude，slope，and human activity，the Zedang wide valley basin was divided into eight management zones， including fixed and semi-fixed sandy lands on gentle slopes at mid-low elevations，mobile sandy land，and mountain sandy land near the airport. Eight management modes were proposed，including windbreak and sand-fixation forests，artificial enclosure and restoration，and sand industry development. The region was designated into priority management areas，key management areas，and secondary management areas.［Conclusion］The findings of this research can provide valuable insights for desertification prevention and control in the Zedang wide valley basin of the Yarlung Zangbo River in the future.