Ecological protection measures are effective means to control the slope erosion of completely weathered granite backfill slope. Taking the completely weathered granite backfill slope of Longling section of China-Myanmar oil and gas pipeline as the research object, through the indoor artificial simulated rainfall test, under the same slope length, four soil and water conservation measures (engineering measures, plant measures, engineering + plant measures and engineering + tillage measures) with different slopes (10°, 20°, 30° and 40°) and the same rainfall intensity (220 mm/h) were selected to analyze the change law of soil erosion on slope surface and calculate the flow yield rate and sediment yield rate to evaluate its control effect. The results showed that: (1) The protective measures set up in different slopes could reduce flow and sediment, and the best water and soil conservation measure was engineering+plant measure. (2) The slope≤10°was basically stable under the condition of bare slope, and no protective measure was required. For 10°~20° and 20°~30° slopes, the slope protection measures of grass planting (coverage rate 100%) and grass planting+slope interception and drainage measures are effective. For slopes ＞30°, biological measures must be set on the slope surface on the basis of slope consolidation measures to effectively control slope erosion. (3) The threshold of slope was not fixed. The more complex the slope protection measures were, the greater the threshold was. Under different protective measures, the slope had the greatest impact on the cumulative sediment yield.