Cadmium (Cd) and arsenic (As) are the dominant heavy metal pollutants widely existing in the soil environment, which have the characteristics of non-degradability and bioaccumulation. Therefore, remediation of Cd and As pollution should be carried out in time. The study took the farmland soil polluted by medium and light Cd and As in Hunan Province as the object, and selected the local dominant plants. In the field experiment, the compound passivator of biochar and nano-zero-valent iron were added, and the matching planting modes of different plants (rape-broad bean and corn-ramie) were used, and the through the field experiment, the remediation effect of plant rotation and the application of compound passivator on Cd and As pollution in soil was explored. The results showed that: (1) The plant rotation models (fava bean-rapeseed, corn-ramie) were more favorable to the fixation of Cd and As in the soil, and the best fixation effect of Cd and As in the test soil was 45.19% and 19.00% of the original soil, respectively. (2) The compound passivator significantly enhanced the fixation of Cd and As in agricultural soil. The passivation effects on Cd and As were the most obvious when biochar and nano-zero-valent iron were applied in the ratio of 53∶1. (3) Applying compound passivators in intercropping mode could effectively promote the remediation effect of Cd and As contaminated soil. This method was more suitable for the application of remediation engineering of moderate and light Cd and As contaminated soil. The optimal ratio of compound passivators and the use of intercropping pattern provide an experimental basis and theoretical support for the remediation and treatment of Cd and As contaminated soil.