The application of activated water treatment technologies such as magnetization and de-electronic in agricultural irrigation has been widely concerned. In order to clarify the influence mechanism of magnetization-de-electronic water infiltration on soil water and salt transport, one-dimensional vertical infiltration test was conducted with tap water, magnetized water (0.4 T), de-electronic water and magnetization-de-electronic integral activation water, and the effect of magnetization-de-electronic integrated activation water on soil water and salt transport characteristics and salt leaching efficiency were studied. The results showed that compared with the control, the magnetization-de-electronic integrated activation treatment could effectively promote soil moisture infiltration, increase soil water content, reduce soil salinity, and improve the salt leaching efficiency of irrigation water. Moreover, the magnetization-de-electronic integrated activation water had different degrees of improvement in the infiltration capacity, soil water content, soil salinity, and salt leaching efficiency compared with the single magnetization or de-electronic method. Compared with de-electronic water, in the treatment of magnetization-de-electronic integrated activation water, the cumulative infiltration of increased by 28.0%, the time to reach the end of infiltration decreased by 25.7%, the soil moisture content of the 15 cm depth layer increased by 7.9%, and the overall soil desalination rate increased by 13.9%. Compared with magnetized water, in the treatment of magnetization-de-electronic integrated activation water, the cumulative infiltration increased by 6.7%, the time to reach the end of infiltration decreased by 12.2%, the soil moisture content of the 15 cm depth soil layer increased by 3.2%, and the overall soil desalination rate increased by 4.7%. The study results showed that magnetization-de-electronic integral activation water had a significant promotion effect on soil salt leaching, and its promotion effect was more obvious than that of magnetized water or de-electronic water, which was beneficial to create a good water and salt environment for crop growth, and provided a reference for the rational utilization of magnetization-de-electronic integral activation water.