In 2017 and 2018, a field experiment with three regulated deficit irrigation amounts (non-deficit E1:100% of ET0, moderate deficit E2:80% of ET0, severe deficit E3:60% of ET0) and two wheat varieties (water-sensitive type X1:Xin Chun 22, water-insensitive type X2:Xin Chun 44) were conducted with drip irrigation for spring wheat in northern Xinjiang. The same nitrogen level of 300 kg/hm² and same irrigation frequency of one irrigation every 7 days were implemented. The soil moisture, nitrate nitrogen distribution and yield of spring wheat were studied. The results showed that:(1) These water deficit (E3) could alleviate soil water and nitrate nitrogen loss from 0-40 cm to the deep, it also reduced crop water consumption and improved water use efficiency. (2) There was no significant difference in soil mass moisture contents and soil nitrate nitrogen contents between Xin Chun 22 and Xin Chun 44, and wheat varieties had little influence on soil physical and chemical properties. (3) In moderate water deficit (E2), Xin Chun 44 (X2) saved a lot of water, and simultaneously, it improved water use efficiency and maintained the optimum nitrogen nutrition index (NNI).And consequently, the output was significantly compensated. But Xin Chun 22 (X1) could not be effectively compensated by moderate and severe water deficit. (4) With the same level of the nitrogen application and irrigation frequency, the wheat varieties had greater effects than the levels of regulated deficit irrigation on drip irrigation water use efficiency of spring wheat. (5)Taking into account NNI, water consumption, water utilization efficiency and yield, Xin Chun 44 (X2) was more suitable plant with regulated deficit irrigation model in northern Xinjiang, and its optimal regulated deficit irrigation treatment was E2.