As a result of the controlled release of nutrients, controlled release fertilizer (CRF), used once, can meet the nutrient demand of field crops for more than 4 months, which can realize the efficient use of fertilizer. Now it is applied successfully in field crops. For this reason, according to the law of tomato nutrient absorption in solar greenhouse, four kinds of different CRF treatments (A, B, C, D) were established through added different quantity of controlled release urea and potassium chloride into growth-bag substrate, the paper investigated the effects of different CRF treatments on the growth-bag substrate nutrient change, and the growth, yield and quality of tomato in solar greenhouse compared with no fertilizer (CK) and conventional fertilization (CKT). The experiment results showed that with the increase of CRF dosage, tomato plants growth and yield showed a change trend of first increase and then decrease. Among all treatments, the treatment C was the best, of which the substrate EC value was stable, the nutrient content of available nitrogen, phosphorus and potassium in growth-bag substrate of treatment C became slightly lower than that at the beginning; Compared with CK, the plant height increased by 21.75%, the stem width increased by 59.46%, the biomass accumulation increased by 75.12%, the yield increased by 226.36%, and the fruit quality was much improved. Compared with CKT, little nutrient was left in the substrate and the fruit yield increased by 24.48%. The experiment result indicates that CRF could increase the nutrient use efficiency and fruit yield for substrate growth-bag of tomato in solar greenhouse.