China has carried out the strategy of western region exploitation since 1997. More and more organiza- tions and people started to care of the eco-environmental issues in western China again. The plan aimed at moni- toring the eco-environmental change in western region with remote sensing over the period of 1990 to 2000 and supplied scientific decision-making for national strategy of western region exploitation. The study selected 7 typi- cal sites in western region in first stage, adopted the methodology of integrated remote sensing and GIS technolo- gy, laid a guide to eco-environment monitoring with remote sensing to dynamic monitoring eco-environment change in these regions from 1990 to 2000 according to 8 uniform rules. The results show the land for agriculture and city construction increased with occupying the land for natural and semi natural vegetation. And the regions are subject to the developing trend of eco-environment degradation.