Changes of vegetation condition and soil fertility were studied continuously from 1998 to 2000 on the mixture grassland of perennial grasses established in Jingqianghe region(3 000 m a.s.l), one of the regions of estern Tibetan Plateau. The results show that the vegetation coverage can be increased, the soil erosion can be lessened and the soil fertility can be improved by establishing mixture grassland of the perennial grasses in this region. The results also indicate that the economic benefit of the mixture grassland is significant, the input/output ratio, output/labor ratio and the net income from per unit area of the mixture grassland are higher than the oat land, grazing grassland and fenced grassland. In conclusion, properly establishing and developing the mixture grassland of perennial grasses is a key option to keep high productivity and sustainable development of the grassland ecosystem in alpine regions of Tibetan Plateau.