In order to explore the solidification effect of microbially induced calcium carbonate precipitation (MICP) and plant technology on contaminated mining areas, Lysinibacillus fusiformis, Suaeda salsa and Reamuria songarica were used to carry out the solidification experiment of tailings pollution in arid and semi-arid high wind erosion area. The response effect of contaminated mining area was characterized by plant root tension and root-soil composite shear strength. The results showed that the root tensile strength of R. soongorica and S. salsa increased by 59.9% and 19.7%, and the shear strength decreased by 7.4% and 22.5% after MICP treatment. Compared with before MICP treatment, the shear strength of red sand and S. salsa complex increased by 62.7% and 45.9% at 100 kPa. 200 kPa increased by 130%, 122%; 26.8%, 30.6% at 300 kPa. After cementation, the contents of hemicellulose, cellulose and lignin in the roots of R. soongorica and S. salsa increased significantly (p < 0.05), and the roots of R. soongorica increased by 64%, 74% and 153%, respectively. Suaeda salsa roots increased by 24%, 46%, 95% respectively. In summary, MICP synergistic vegetation provides an efficient and feasible new way for pollution remediation in arid and semi-arid high wind erosion tailings areas. Secondly, the research results can improve the natural environment of the mining area.