The purpose of this study was to investigate the effects of sprinkler irrigation uniformity coefficient (CU) on soil moisture, crop yield and water use efficiency, and to explore the suitable tillage patterns under sprinkler irrigation conditions. Field experiments, which included rotary tillage (RT), subsoiling (ST) and conventional tillage (CT), were conducted during the winter wheat growing season in 2018-2019 with three plots of 18 m×18 m. Each plot was subdivided into 9 subplots of 6 m×6 m. The results showed that the average CU of sprinkler irrigation varied between 63.91%~76.83%, while the CU of soil moisture varied between 84.20%~89.83%, which were 14.48%~31.75% higher than the former. The CU of winter wheat yield were 9.99%~23.79% higher than the average CU of sprinkler irrigation, 2.11%~7.85% lower than the cumulative irrigation CU, and 0.82%~6.04% different from the averaged values of soil moisture CU. Compared with RT treatment, the yield of winter wheat in ST and CT treatments increased by 9.38% and 13.22%, respectively, and the water use efficiency increased by 10.61% and 12.88%, respectively. That was, compared with the sprinkler irrigation CU, the CU of winter wheat yield were more affected by those of the cumulative irrigation CU and the averaged values of soil moisture CU. ST and CT treatments were the suitable farming method under the sprinkler irrigation condition.