Field experiment was conducted to investigate the dynamic changes of soil pH, organic matter and cadmium (Cd) content in soil and Cd accumulation in rice organs at different growth stages under applying different amounts of organic fertilizer and lime. The results showed that Cd content in different organs of rice at the maturity stage followed the order of root > stem > leaf > husk > brown rice. The application of lime could increase the soil pH. At the tillering stage, the soil pH significantly increased by 1.35 and 1.84 units under the treatment of low amount lime and high amount lime, respectively.The application of organic fertilizer could increase the organic matter content. Compared with the control, the content of organic matter increased by 6.60 g/kg at tillering stage and 2.72 g/kg at maturity stage in the treatment of high amount of organic fertilizer.The filling stage was an important period for the absorption and accumulation of Cd in rice. The application of lime and organic fertilizer could reduce the available Cd content in the soil during the filling stage.Compared with the control group, the content of available Cd in soil treated with high amount organic fertilizer and lime significantly decreased by 52.05% and 46.87%, respectively. Both organic fertilizer and lime could significantly reduce the Cd content of brown rice, and the effect of reducing Cd followed the order of high amount of organic fertilizer > high amount of lime > low amount of organic fertilizer > low amount of lime, the effect of high amount organic fertilizer treatment was the best, Cd content of brown rice decreased by 68.20%.