In order to improve the utilization rate of urea nitrogen and promote the research and development of new slow/controlled release nitrogen fertilizer, a pot experiment, which including five treatments as control (CK), common urea (U), U + common urease inhibitor HQ (SRU1), U + coated HQ (SRU2), and U + 30% common HQ+70% coated HQ (SRU3), were conducted to study the effect of partially or completely coated HQ mixed with urea on wheat growth, soil nitrogen, and urease activity. The results showed that compared with SRU1, coated HQ can promote wheat growth, improve wheat yield components, increase wheat yield, and improve nitrogen utilization rate. SRU2 and SRU3 respectively increased the yield of wheat by 34.71% and 56.54%. Compared with SRU2, SRU3 treatment of common HQ mixed with Coated HQ could effectively inhibit the hydrolysis of urea at the early stage, maintain the appropriate concentration of NH₄⁺-N in soil, and increase the content of NH₄⁺-N at the later stage, so as to ensure the continuous supply of available nitrogen in the soil, reduce the loss of nitrogen, and maintain the urease activity of soil at a low level for a long time in the whole growth period of wheat. SRU3 treatment had the strongest nitrogen supply capacity and the highest nitrogen utilization rate in soil, and had the most significant effect on the growth of wheat.