To effectively control soil erosion and non-point source pollution of slope-farmland in purple hilly, the paper mainly studied the effect of different conservation measures on runoff, sediment and nutrient loss at natural rainfall conditions and crop yield of slope farmland by runoff plots location observation method, which deeply revealed the effect of biological carbon, poly propylene amide and straw mulching measures on controlling soil nutrient loss from slope farmland. Results indicated that: (1)Compared with the background value, the increase of soil nutrient content showed as SM (straw mulching)>PAM (polyacrylamide)>BC (biological carbon), which indicated that the corn straw mulching measures could improve soil nutrient best, followed by polyacrylamide. (2)The effects of different soil management measures to control the runoff and sediment yield changed in order as SM>PAM>BC. Measures of BC, PAM, SM could reduce runoff 0.00%-54.55%, 0.00%~85.79%, 0.00%~92.39%, respectively, and the amount of sediment yield decreased by 2.67%~47.78%, 5.87%~77.90%, 11.47%~90.17%. In the medium and heavy rain, the effect of protective measures on reducing runoff and sediment was significant, but it was waked in rainstorm. (3)The effect of soil management measures on controlling nitrogen loss was in order as SM>PAM>BC. Compared with CK, under medium and heavy rain conditions, the total nitrogen loss of protection measures was reduced by 16.24%~76.29%, and hydrolytic nitrogen loss was reduced by 6.21%~81.93%; under the rainstorm condition, nitrogen loss was reduced by （-11.74%）~11.99%; hydrolytic nitrogen loss was reduced by （-9.87%）~17.39%. The results showed that corn straw mulching was the best method to control nitrogen loss. (4)The effect of different soil management measures on controlling the phosphorus loss was different. Protective measures of BC, PAM and SM under middle and heavy rain conditions could control total phosphorus loss effectively (15.00%~81.44%), and the effect weakened ((-6.68%)~10.98%) under rainstorm condition. Compared with CK, the effect of protection measures on increasing corn grain yield was in order as SM (29.43%)>PAM (19.01%)>BC (12.66%). The soil management measures of biological carbon, polyacrylamide and straw mulching controlled soil nutrient loss from slope farmland effectively, and straw mulching measure controlled the best.