The pot experiments were conducted to study the effects of lake sediment and inorganic fertilizer combined application on soil chemical properties and heavy metal(Cd) of winter wheat seed.The results showed that content of nutrients could be increased in the soil by combined application of lake sediment and inorganic fertilizer,although content of heavy metals(Cd,Pb,Cu,Zn) could be increased,the soil was clean.The content of heavy metals of Cd in wheat seed of different treatments were not exceeded the National Control Hygienic Standard for Foods,the amount of combined application was the safe and economical,if lake sediment was 200 t/hm2 and inorganic fertilizer was 150 kg/hm2(CO(NH_2)_2) 150 kg/hm2((NH_4)_2HPO_4).