In order to explore the comprehensive control measures of soil salinity in the Hetao irrigation area, taking the Jiefangzha irrigation area as an example, the effects of irrigation water salinity, the mixing ratio of saline and fresh water, the depth of drainage ditch and the level of channel lining on soil salinity in root zone were studied using the SaltMod model. The results showed that the soil salinity in the root layer increased with the increase of the irrigation water salinity, and the surface brackish water of 1.0 g/L was more suitable for irrigation in this study area; when the mixed irrigation ratio of fresh water (Yellow River water) and underground brackish water (salinity is 2.2 g/L) was 1：1, the utilization of underground brackish water was increased and the groundwater depth dropped to a relatively stable balance of about 2 m. status; when the drainage depth was between 1.5 and 2.0 m and the canal utilization coefficient reached 0.7, the root layer salinity was significantly reduced. Appropriately increasing the drainage depth and canal water utilization coefficient could effectively reduce the accumulation of soil salt induced by high-salinity irrigation water. The results of this study could provide a scientific theoretical basis for formulating reasonable comprehensive control measures for soil salinity in the Jiefangzha irrigation area of the Hetao Irrigation District.