In order to study the influence of multiple factors on soil water movement characteristics of muddy water film hole fertilizer solution infiltration, indoor soil box infiltration test was carried out. Four experimental factors including initial soil moisture content, soil bulk density, sediment concentration of muddy water and fertilizer solution concentration, 3 levels for each factor, and 12 groups of experiments (9 of orthogonal experiments and 3 of validation experiments). The effects of each factor on cumulative infiltration volume per unit membrane hole area, infiltration rate and average volume water content increment of muddy water membrane hole irrigation fertilizer solution were analyzed. The empirical model and model parameters of cumulative infiltration per unit membrane pore and average volume moisture content increment of wetting body with experimental factors were deduced and verified by multiple regression. The results showed that the initial moisture content of the soil, soil bulk density and sand content and fertilizer concentration had a significant effect on the cumulative inlet of the unit membrane hole (P<0.01). The degree of influence from large to small was the sand content, soil bulk density, the initial soil moisture content, the concentration of fertilizer. The increase in the average moisture content of the wet body was almost independent of the permeation time. The initial moisture content, sand content and fertilizer concentration of the soil were significantly related to it (P<0.01), and the soil weight was significantly related to it (P<0.05), and the degree of influence from large to small was the initial moisture content of the soil, fertilizer concentration, sand content, soil bulk density. The empirical model and model coefficient established were qualified. The error between the predicted and the measured values was within ±10%, and the precision was good, which could be used to predict the soil moisture infiltration situation when the experimental factors were different.