To study the effects of water-saving irrigation and phosphorus and potassium fertilizer reduction on wheat yield, quality,and water and fertilizer use efficiency, field experiments were conducted to study the effects of drip irrigation (W₁) and micro-sprinkler irrigation (W₂) on water-saving irrigation with constant fertilization as control (CK), four times of irrigation during the growth period (overwintering water, jointing water irrigation 600 m³/hm², reviving water, and grouting water irrigation 300 m³/hm²). Under W₁ and W₂, phosphorus and potassium fertilizer constant (R_PK) and reduced by 20% (R_PK-20), 30% (R_PK-30), and 40% (R_PK-40) were applied with 50% basal fertilizer, and 25% of water and fertilizer were applied in returning green stage and jointing stage respectively, yield and its components, quality characteristics and water use and fertilizer efficiency were investigated and analyzed in 11 treatments. The results showed that the yield of W₁ and W₂ treatments decreased with the increase of phosphorus and potassium fertilizer reduction, and the yield of drip irrigation increased significantly for R_PK-20, was 15.49% higher than that of CK, which was mainly related to the increase of panicle number and grain number per spike. The yield of W₂ was lower than that of W₁ under the same treatment. The protein content, sedimentation value, and settling time of W₁ and W₂ treatments were significantly higher than those of CK. The sedimentation value of R_PK and decreasing treatment was W₁>W₂. W₁ was 42.35%~105.24% higher than CK, W₂ was 36.06%~56.18% higher than CK. The water use efficiency of phosphorus and potassium fertilizer combined with bottom application and top application was higher than that of CK_相. The partial productivity of W₁ and W₂ were higher than that of CK. The same reduction of N, P, and K fertilizer was W₁>W₂. The partial productivity of nitrogen increased significantly by W₁R_PK-20. The effect of phosphorus and potassium fertilizer decreased on soil nutrient content was small in 0—40 cm soil, but the available P content was increased. Comprehensive analysis showed that in the wheat grow region in the south of Shanxi Province, drip irrigation was used for winter wheat, four times irrigation was used for growing period, and 50% basal application, and 25% of water and fertilizer application was integrated topdressing, and 20% reduction of phosphorus and potassium fertilizer yield and water use efficiency were the highest, it is a high-yield and high-efficiency water and fertilizer management mode. The 30% reduction of phosphorus and potassium was the best water and fertilizer management mode.