The aim was to investigate the effects of different wheat cultivars on water use efficiency,water use in deep soil, and wheat yield. The experiment was conducted at Changwu experimental station during 2017—2019. A two-factor experiment was conducted, one factor was cultivar (A: "Changhan 58", B: "Changhang 1"), and another factor was sowing rate (10: 150 kg/hm² of sowing rate, 12: 180 kg/hm² of sowing rate). The effects of different factors on soil water consumption, water use efficiency, and yield at different wheat growth stages were analyzed.The results showed that the average consumption of soil storage water in different test years of "Changhang 1"was significantly higher than that of "Changhan 58". In addition,the number of grain number per panicle, harvest index,yield, and water use efficiency of "Changhang 1" were also remarkably higher than those of "Changhan 58".It was showing that compared with "Changhan 58", "Changhang 1" increased theconsumption of soil water, which may contribute to increase the grain number per panicle and the wheat harvest index, and ultimately lead to higher yield and water use efficiency.