Reasonable tillage and fertilization methods are important measures to achieve the high yield and high efficiency of crops. The research work was conducted to explore the effects of different tillage and fertilization methods on nitrogen (N) utilization, yield and soil bulk density of summer maize. In 2016-2017, three treatments of tillage and fertilization were designed, including T1 (no-tillage + upper application of NPK), T2 (subsoiling + whole layer application of NPK) and T3 (application of N, P, K fertilizers to designated different soil depth with subsoiling). Compared with T1, the dry matter accumulation and total N accumulation of T2 and T3 at the mature stage increased by 9.68% and 13.97%, respectively, and the average yield of summer maize enhanced by 17.20%. Compared with T1, the N production efficiency and agronomic efficiency of T2 and T3 improved by 14.74% and 59.95%, respectively, and the apparent N utilization efficiency increased by 14.15% on average, while the soil bulk density of 0-40 cm decreased by 8.54%. Under the deep pine cultivation method, compared with T2, the dry matter and total N accumulation of T3 at the mature stage increased by 9.41% and 6.28%, respectively, and the average grain yield raised by 9.70%, the N production and agronomic efficiency of T3 increased by 8.59% and 32.32%, respectively, and the apparent N utilization efficiency increased by 14.10%. Compared with T1, T2 and T3 increased the yield of summer maize and the utilization of N fertilizer and significantly reduced soil bulk density. The combination of controlled release N fertilizer and deep pine with two-fertilizer ectopic stratified fertilization (T3) could more effectively reduce soil bulk density, increase grain yield and N use efficiency. It is a new type of tillage and fertilization method recommended of summer maize production in the Huanghuaihai Plain.